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Image Search Results
Journal: Drug Design, Development and Therapy
Article Title: Forsythoside B Mitigates Monocrotaline-Induced Pulmonary Arterial Hypertension via Blocking the NF-κB Signaling Pathway to Attenuate Vascular Remodeling
doi: 10.2147/DDDT.S444605
Figure Lengend Snippet: FTS•B relieved MCT-induced PAH and vascular remodeling in rats. Rats received intraperitoneal injection of MCT with/without cotreatment with FTS•B. ( A ) Echocardiographic PW Doppler tracing of pulmonary artery outflow. PAT, PET and quantitative PAT and PAT/PET data (n = 6). ( B ) RVFWT and RVEDD in M-mode echo and quantitative data of RVFWT and RVEDD (n = 6). Quantitative analysis of the mPAP ( C ) and RVSP ( D ) (n = 6). ( E ) Survival curves of the rats during the 21-day period (n = 20). ( F ) Representative images of H&E staining of heart sections (scale bar = 2 mm) and quantitative analysis of the RV/ (LV + S) (n = 6). ( G ) Representative images of H&E staining of lung sections (scale bar = 50 μm) and quantitative analysis of the WT (n = 6). ( H ) Representative images of α-SMA immunohistochemical staining of the pulmonary artery (scale bar = 50 μm). 10–20 pulmonary arteries were quantified per rats and quantitative assessments of muscularized distal arterioles (diameter 25–100 μm, n = 6). ( I ) Representative images of PCNA immunohistochemical staining of the pulmonary artery (scale bar = 50 μm) and quantitative analysis of PCNA-positive cells in the pulmonary artery (n = 6). The data are presented as the mean ± SD. * p < 0.05, ** p < 0.01.
Article Snippet: Mean pulmonary artery pressure (mPAP) and
Techniques: Injection, Staining, Immunohistochemical staining
Journal: Drug Design, Development and Therapy
Article Title: Forsythoside B Mitigates Monocrotaline-Induced Pulmonary Arterial Hypertension via Blocking the NF-κB Signaling Pathway to Attenuate Vascular Remodeling
doi: 10.2147/DDDT.S444605
Figure Lengend Snippet: NF-κB activation blocked the protective effect of FTS•B against PAH and vascular remodeling. Rats were subjected to MCT and FTS•B with/without cotreatment with PMA. ( A ) Representative Western blotting of p-p65, p65, p-IκBα, IκBα, p-IKKα, IKKα, p-IKKβ and IKKβ in lung lysates, and quantitative data of p-p65/p65, p-IκBα/IκBα, p-IKKα/IKKα and p-IKKβ/IKKβ (n = 6). ( B ) Echocardiographic PW Doppler tracing of pulmonary artery outflow and quantitative analysis of PAT and PAT/PET (n = 6). ( C ) RVFWT and RVEDD in M-mode echo and relative quantification (n = 6). ( D ) Quantitative analysis of the mPAP (n = 6). ( E ) Quantitative analysis of the RVSP (n = 6). ( F ) Representative images of H&E staining of heart sections (scale bar = 2 mm) and quantitative analysis of the RV/ (LV + S) (n = 6). ( G ). Representative images of H&E staining of lung sections (scale bar = 50 μm) and quantitative analysis of the WT (n = 6). ( H ) Representative images of α-SMA immunohistochemical staining in the pulmonary artery (scale bar = 50 μm) and quantitative assessments of muscularized pulmonary arteries (n = 6). ( I ) Representative images of PCNA immunohistochemical staining in the pulmonary artery (scale bar = 50 μm) and quantitative data of PCNA-positive cells (n = 6). The data are presented as the mean ± SD. * p < 0.05, ** p < 0.01.
Article Snippet: Mean pulmonary artery pressure (mPAP) and
Techniques: Activation Assay, Western Blot, Quantitative Proteomics, Staining, Immunohistochemical staining